SYDNEY: Australian researchers in a pioneering study have identified the ‘blood-to-brain pathway’ that may lead to Alzheimer’s disease, offering potential new prevention and treatment opportunities for the debilitating brain disorder, which It is the most prevalent form of dementia globally. The study, led by a cohort team at Curtin University in Perth, Australia, tested on a mouse model, showed that a possible cause of Alzheimer’s disease was the leakage from the blood into the brain of fat particles carrying toxic proteins. The findings are published in the journal PLOS Biology.
The principal investigator, Professor John Mamo, director of the Curtin Health Innovation Research Institute (CHIRI), said his collaborative group of Australian scientists has identified a potential ‘blood-to-brain pathway’ that could lead to Alzheimer’s disease, a disease that causes dementia globally. is the most popular form.
“While we previously knew that the hallmark feature of people with Alzheimer’s disease was the progressive accumulation of toxic protein deposits within the brain called beta-amyloid, researchers did not know where amyloid originated, or why it accumulated in the brain. ,” said principal investigator Professor John Mamo, director of the Curtin Health Innovation Research Institute (CHIRI).
“This ‘blood-to-brain pathway’ is important because if we can manage blood levels of lipoprotein-amyloid and stop their leak into the brain, it could potentially lead to preventing Alzheimer’s disease and slowing memory loss.” Opens up new treatments,” Mamo added.